Caspofungin analog and applications thereof

US8969513B2 · kind B2 · utility

Assignee

• SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD. · CN

Inventors

• Bingming He · Shanghai, CN
• Ming Li · Suzhou, CN
• Zhijun Tang · Shanghai, CN
• Xiaoming Ji · Sunnyvale, US

Key dates

• Filing date: Nov 10, 2011
• Grant date: Mar 3, 2015
• Expiry date: Nov 10, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are a caspofungin analog and applications thereof. The caspofungin analog is a compound having a structure as indicated in Formula (4), or pharmaceutically acceptable salts thereof. R1 can be chosen from hydroxyl, benzyloxy, phenoxy, substituted phenoxy, or substituted benzyloxy. R2, R3, R4, R5 can be chosen from hydrogen, C1-C6 alkyl, C1-C6 alkoxy, hydroxyl, benzyloxyphenyl, substituted benzyloxyphenyl, nitro, fluorine, chlorine, bromine, or iodine. Also disclosed are a preparation method for and applications of the compound.