Patent · US Active

Formulation of sugar solutions for continuous ultracentrifugation for virus purification

US8969533B2 · kind B2 · utility

2Cited by

2References

31Claims

0Family size

Assignees

Baxter International Inc. · US
Baxter Healthcare SA · CH

Inventors

Manfred Reiter · Wien, AT
Leopold Grillberger · Wien, AT
Wolfgang Mundt · Wien, AT
Artur Mitterer · Orth an der Donau, AT
Horst Schafhauser · Wien, AT

Key dates

Filing date	Apr 30, 2008
Grant date	Mar 3, 2015
Priority date	—
Expiry date	Aug 25, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2760/16252
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention provides a method for purification of a virus or virus antigen comprising providing a virus preparation and centrifugation of said virus preparation in a gradient of a sugar established by the addition of two or more buffered sugar layers of different concentration. The method leads to higher yields and reduces unwanted aggregation of the virus or virus antigen by increasing the volume of the peak pool.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.