Compounds useful in imaging and therapy
US8969546B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 27, 2011 |
| Grant date | Mar 3, 2015 |
| Priority date | — |
| Expiry date | Jun 27, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0057
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided in the following specification are precursors or synthons that are useful for the synthesis of various arabinose based chemical and radiochemical derivatives of nitroimidazole-containing azomycin arabinosides, such as radioiodinated 1-#-D-(5-deoxy-5-[I*]-iodoarabinofuranosyl)-2-nitroimidazole (*IAZA), and radiofluorinated 1-#-D-(5-deoxy-5-[18F]-iodoarabinofuranosyl)-2-nitroimidazole (18FAZA). Such compounds are useful in imaging, therapy, or radiotherapy. Further, various syntheses of said precursors/synthons and the incorporation of said precursors/synthons into kits is provided. The precursors/synthons provided herein allow for an improved and facile manufacturing process for nitroimidazole-containing azomycin arabinosides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.