Imidazo[1,2-b]pyridazine-based compounds, compositions comprising them, and methods of their use

US8969565B2 · kind B2 · utility

Assignee

• LEXICON PHARMACEUTICALS, INC. · US

Inventors

• Yingzhi Bi · Plainsboro, US
• Kenneth G. Carson · Princeton, US
• Giovanni Cianchetta · Waltham, US
• Michael Alan Green · Easton, US
• Godwin Kwame Kumi · Morrisville, US
• Zhi-Zhong Liang · Toronto, CA
• Ying Liu · Lawrenceville, US
• Alan J. Main · Far Hills, US
• Yulian Zhang · San Diego, US
• Gregory Glenn Zipp · Lawrence, US

Key dates

• Filing date: Mar 5, 2013
• Grant date: Mar 3, 2015
• Expiry date: Mar 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Imidazo[1,2-b]pyridazine-based compounds of the formula:are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.