Enzymatic degradation of lipid A fatty acids of bacterial LPS
US8975043B2 · kind B2 · utility
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Key dates
| Filing date | Nov 23, 2006 |
| Grant date | Mar 10, 2015 |
| Priority date | — |
| Expiry date | Nov 9, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6037
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel enzymes, processes and antigenic structures useful in producing vaccines and compounds useful in combating gram-negative bacteria are described. Enzymes were isolated from the slime mold Dictyostelium discoideum and used to specifically degrade lipopolysaccharide (LPS). Enzymatic degradation permits residues of the LPS molecule, including immunogenic epitopes of the core oligosaccharide portion of the LPS, to remain unmodified during this enzymatic removal of fatty acids from the lipid A region of the LPS molecule.
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