Enhanced production of isoprene using host cells having decreased ispA activity
US8975051B2 · kind B2 · utility
4Cited by
3References
56Claims
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Key dates
| Filing date | Dec 21, 2012 |
| Grant date | Mar 10, 2015 |
| Priority date | — |
| Expiry date | Dec 21, 2032 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/52
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This invention relates to recombinant microorganisms capable of producing isoprene and isoprene production with the use of such recombinant microorganism with good efficiency. In this invention, functional activity of the ispA gene is altered to reduce the production of isoprenoid molecules in recombinant cells engineered to produce isoprene or in cells otherwise susceptible to isoprenoid accumulation during fermentation. This decreased ispA gene functional activity enables enhanced synthesis of isoprene in a host microorganism.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.