Bone morphogenic protein binding peptide

US8975231B2 · kind B2 · utility

Assignees

• The Regents of the University of California · US
• THE UNITED STATES OF AMERICA REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS · US

Inventors

• Samuel S. Murray · Santa Clarita, US
• Elsa J. Brochmann-Murray · Santa Clarita, US
• Jeffrey C. Wang · West Hollywood, US
• Keyvan Behnam · Simi Valley, US

Key dates

• Filing date: Jun 1, 2012
• Grant date: Mar 10, 2015
• Expiry date: Jun 1, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/155
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2, as do endogenous forms of BBP, and sequence conservation between species results in a variety of useful BBP compositions. BBP increases the over-all osteogenic activity of rhBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.