Process for the asymmetric transfer hydrogenation of ketones

US8975396B2 · kind B2 · utility

Assignee

• Euticals GmbH · DE

Inventors

• Richard Wisdom · Cambridge, GB
• Joerg Jung · Frankenthal (Pfalz), DE
• Andreas Meudt · Hofheim, DE

Key dates

• Filing date: Apr 14, 2011
• Grant date: Mar 10, 2015
• Expiry date: Oct 10, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention relates to a process for the asymmetric transfer hydrogenation of a ketone substrate to produce as chiral secondary alcohol with an ee of greater than 85% in which an enantio-enriched chiral catalyst containing ruthenium or rhodium is used with a hydrogen donor and in which an anion exchange resin is used as a base.