Aliphatic prodrug linker

US8980242B2 · kind B2 · utility

Assignee

• Ascendis Pharma Inc. · DE

Inventors

• Dirk Vetter · Heidelberg, DE
• Harald Rau · Würzburg, DE
• Thomas Wegge · Heidelberg, DE
• Ulrich Hersel · Heidelberg, DE

Key dates

• Filing date: Jun 21, 2006
• Grant date: Mar 17, 2015
• Expiry date: May 17, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A polymeric prodrug is described which comprises at least one polymer attached via at least one permanent bond to a bicine linker. The bicine linker is attached via a temporary linkage to an amine containing biologically active moiety. The amine containing biologically active moiety—such as a drug—can be released by cleaving the temporary linkage.