Targeted heterologous antigen presentation on calicivirus virus-like particles
US8980275B2 · kind B2 · utility
20Cited by
1References
26Claims
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Assignee
Inventors
Key dates
| Filing date | Jan 21, 2011 |
| Grant date | Mar 17, 2015 |
| Priority date | — |
| Expiry date | Jan 21, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/16034
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides particle-forming chimeric proteins comprising a Calicivirus capsid protein and one or more heterologous antigen sequences. In particular, the present invention discloses engineered Calicivirus capsid protein sequences containing heterologous epitopes fused at internal locations such that the modified capsid proteins retain the ability to form virus-like particles when expressed in host cells. Virus-like particles comprising the chimeric proteins and vaccine formulations are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.