Bio-functionalized stimulus-responsive dissolvable PEG-hydrogels

US8980278B2 · kind B2 · utility

Assignees

• UNIVERSITAETSKLINIKUM FREIBURG · DE
• Albert-Ludwigs-Universitaet Freiburg · DE

Inventors

• Thorsten Steinberg · Mannheim, DE
• Wilfried Weber · Wittlich, DE
• Raphael Guebeli · Darmstadt, DE
• Pascal Tomakidi · Teningen, DE
• Dougal Laird · Glückstadt, DE

Key dates

• Filing date: Nov 18, 2011
• Grant date: Mar 17, 2015
• Expiry date: Nov 18, 2031

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention is directed to a bio-functionalized stimulus-responsive dissolvable PEG-hydrogel. This inventive stimulus-responsive dissolvable PEG-hydrogel comprises a matrix of PEG-polymers, which are modified to contain at least one multifunctional fusion protein, the multifunctional fusion protein preferably comprising as components a substrate binding peptide (SBP), preferably a repetitive RGD-binding peptide and/or a ZZ-binding domain, preferably a tag for purification, and at least one N- and/or C-terminal linker. The present invention is furthermore directed to the use of such inventive stimulus-responsive dissolvable PEG-hydrogels in the treatment of lesions, in surgical dressings, for wound treating, for soft and hard tissue regeneration, for the treatment of wounds in the oral cavity, in the field of ophthalmology, in the field of periodontal defects, etc. The invention also describes a method of treatment for such diseases. Additionally, the present invention provides a kit comprising the inventive stimulus-responsive dissolvable PEG-hydrogel and optionally further components.