Patent · US Active

Silicon dioxide nanoparticles and the use thereof for vaccination

US8980324B2 · kind B2 · utility

0Cited by

1References

8Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Markus Weigandt · Mannheim, DE
Andrea Hanefeld · Darmstadt, DE
Armin Kuebelbeck · Bensheim, DE
Gregor Larbig · Gelnhausen, DE

Key dates

Filing date	Jul 13, 2009
Grant date	Mar 17, 2015
Priority date	—
Expiry date	May 14, 2030

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10T428/2982
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. The invention also relates to a method for the targeting of antigens at antigen-presenting cells and for the activation of the immune system, where the efficiency of targeting and/or immunoactivation are set via the particle characteristics. The invention also relates to a method for the active and passive immunization of a mammal.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.