Patent · US Active

Method for ameliorating radiation exposure effects with alpha-1 antitrypsin

US8980574B2 · kind B2 · utility

1Cited by
2References
27Claims
0Family size

Inventors

Key dates

Filing dateMar 9, 2012
Grant dateMar 17, 2015
Priority date—
Expiry dateMar 9, 2032

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K38/00
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Embodiments described herein relate to compositions, methods and uses for alpha-1 antitrypsin (AAT) or derivatives or analogs or peptides or mutants thereof for treating a subject exposed to radiation. In certain embodiments, AAT or derivatives thereof or analogs thereof can be used to modulate adverse effects of radiation therapy on subjects undergoing treatment for cancer. In other embodiments, compositions disclosed herein can be used for treating a subject having been exposed to non-therapeutic or accidental radiation. Some embodiments reported herein concern compositions and methods for enhancing radiotherapy. Certain embodiments relate to methods and compositions for preventing or reducing radiation exposure-induced cellular damage in a subject.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.