Use of a protein homologous to a MeaB protein for increasing the enzymatic activity of a 3-hydroxycarboxylic acid-CoA mutase

US8980594B2 · kind B2 · utility

Assignee

• Evonik Röhm GmbH · DE

Inventors

• Liv Reinecke · Essen, DE
• Steffen Schaffer · Herten, DE
• Tim Koehler · Dorsten, DE
• Anja Thiessenhusen · Munster, DE
• Achim Marx · Bielefeld, DE
• Markus Buchhaupt · Niederdorfelden, DE

Key dates

• Filing date: Oct 11, 2010
• Grant date: Mar 17, 2015
• Expiry date: Oct 11, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to the use of a protein homologous to a MeaB protein for increasing the enzymatic activity of a 3-hydroxycarboxylic acid-CoA mutase, a fusion protein comprising a 3-hydroxycarboxylic acid-CoA mutase and a protein sequence homologous to a MeaB protein and an enzymatic method for producing 2-hydroxyisobutryric acid.