Mutant glycerol dehydrogenase (GlyDH) for the production of a biochemical by fermentation
US8980604B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 30, 2010 |
| Grant date | Mar 17, 2015 |
| Priority date | — |
| Expiry date | May 27, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/0006
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention concerns a method for the production of 1,2-propanediol, comprising culturing a microorganism modified for an improved production of 1,2-propanediol in an appropriate culture medium and recovery of the 1,2-propanediol which may be further purified wherein the microorganism expresses a glycerol dehydrogenase (GlyDH) enzyme the inhibition of which activity by NAD+ and/or its substrate and/or its product is reduced.The present invention also relates to a mutant glycerol dehydrogenase (GlyDH) comprising at least one amino acid residue in the protein sequence of the parent enzyme replaced by a different amino acid residue at the same position wherein
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.