Patent · US Active

Cyclized peptidomimetic small molecule inhibitors of the WDR5 and MLL1 interaction

US8980838B2 · kind B2 · utility

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7Claims

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Assignee

THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

Shaomeng Wang · Saline, US
Hacer Karatas · Ann Arbor, US
Yali Dou · Ann Arbor, US
Elizabeth Townsend · Ann Arbor, US
Denzil Bernard · Ann Arbor, US
Fang Cao · Suzhou, CN

Key dates

Filing date	Nov 27, 2012
Grant date	Mar 17, 2015
Priority date	—
Expiry date	Nov 27, 2032

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61N2005/1098
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Cyclic peptidomimetics that inhibit the interaction between MLL1 and WDR5 are disclosed. Methods of inhibiting MLL1 activity and methods of treating cancers also are disclosed.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.