2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof

US8980887B2 · kind B2 · utility

Assignees

• Institute of Pharmacology · CN
• Toxicology Academy of Military Medical Sciences P.L.A., China · CN

Inventors

• Rifang Yang · Beijing, CN
• Yunfeng Li · Beijing, CN
• Yongzhen Li · Beijing, CN
• Nan Zhao · Beijing, CN
• Liuhong Yun · Beijing, CN
• Juanjuan Qin · Beijing, CN
• Zhongyao Feng · Beijing, CN
• Youzhi Zhang · Beijing, CN

Key dates

• Filing date: Jun 9, 2011
• Grant date: Mar 17, 2015
• Expiry date: Jun 9, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are 2-arylimidazo[1,2-a]pyridine-3-acetamide derivatives represented by formula I, their tautomer, racemate or optical isomer, their pharmaceutically acceptable salt, or their solvates, wherein R1, R2, R3 and R4 are defined as in the specification. Preparation methods of said compounds and use of said compounds in treating and/or preventing central nervous system disease associated with TSPO functional disorder