Process for the synthesis of pemetrexed disodium salt
US8981090B2 · kind B2 · utility
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22Claims
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Key dates
| Filing date | Jul 5, 2011 |
| Grant date | Mar 17, 2015 |
| Priority date | — |
| Expiry date | Jul 9, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2by purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solventcharacterized in that the mixture is subjected to the following steps:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.