Substituted 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-ones as modulators of protein kinase activity

US8981092B2 · kind B2 · utility

Assignee

• NERVIANO MEDICAL SCIENCES S.R.L. · IT

Inventors

• Danilo Mirizzi · Milano, IT
• Giovanni Cervi · Como, IT
• Matteo D'Anello · Novate Milanese, IT
• Gianluca Mariano Enrico Papeo · Merate, IT
• Ron Ferguson · Scotch Plains, US
• Francesco Casuscelli · Busto Garolfo, IT

Key dates

• Filing date: Jan 23, 2013
• Grant date: Mar 17, 2015
• Expiry date: Jan 23, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds which are 4,7-disubstituted derivatives of 3,4-dihydro-2H-pyrrolo[1,2-a]pyrazin-1-one compounds,or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.