Process for the preparation of nitrogen substituted aminotetralins derivatives

US8981121B2 · kind B2 · utility

Assignee

• UCB Pharma GMBH · DE

Inventors

• Celal Ates · Louvain-la-Neuve, BE
• Arnaud Schule · Brussels, BE
• Magali Palacio · Brussels, BE
• Paul Deutsch · Kansas City, US
• David Vasselin · Brussels, BE
• Nicolas Carly · Brussels, BE
• Ganesh Phadtare · Jamkhed, IN
• Swapnil Yerande · Ahmedabad, IN
• Jean-Pierre Delatinne · Brussels, BE
• Maria Luisa Escudero Hernandez · Parma, IT
• Veronique Pinilla · Brussels, BE

Key dates

• Filing date: Jun 24, 2011
• Grant date: Mar 17, 2015
• Expiry date: Jul 2, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2602/10
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides an alternative synthesis of N-substituted aminotetralines comprising resolution of N-substituted aminotetralins of formula (II), wherein R1, R2 and R3 are as defined for compound of formula (I).