Methods and system for detecting soluble amyloid-β
US8986657B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jul 29, 2010 |
| Grant date | Mar 24, 2015 |
| Priority date | — |
| Expiry date | Oct 7, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4709
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides methods of detecting soluble amyloid β using curcumin-derived near infrared (NIR) imaging probes. Upon interacting with soluble amyloid β, these probes undergo a range of changes, qualifying them as “smart” probes. In addition, the invention provides methods of detecting soluble amyloid β by positron emission tomography (PET), magnetic resonance imaging (MRI) and multimodal imaging based on the curcumin-derived NIR imaging probes and derivatives thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.