Method to increase the absorption of unsaturated fatty acids by human infants

US8986682B2 · kind B2 · utility

Assignee

• SWEDISH ORPHAN BIOVITRUM AG · SE

Inventors

• Olle Hernell · Umeå, SE
• Birgitta Olsson · Stenhamra, SE
• Patrik Strömberg · Sollentuna, SE
• Lennart Svensson · Visby, SE
• Kristina Timdahl · Tullinge, SE
• Mårten Vågerö · Boo, SE
• Maria Öhman · Piteå, SE

Key dates

• Filing date: Oct 21, 2011
• Grant date: Mar 24, 2015
• Expiry date: Aug 3, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/01003
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a method to increase the absorption by a human infant of at least one unsaturated fatty acid, said method comprising the enteral administration to said infant of recombinant human bile-salt-stimulated lipase (rhBSSL). In another aspect the invention also relates to a method to improve the visual and/or cognitive development of a human infant, said method comprising the enteral administration to said infant of rhBSSL. Such methods have particular utility for preterm human infants, particular those in medical need of increasing their absorption of or availability to such unsaturated fatty acids. In further aspects, the invention relates to kits, packaged-pharmaceutical-products, recombinant human bile-salt-stimulated lipase and pharmaceutical compositions, in each case useful for increasing the absorption by a human infant of at least one unsaturated fatty acid, or for increasing the visual and/or cognitive development of a human infant.