Immunogenic lipopeptides comprising T-helper and cytotoxic T-lymphocyte (CTL) epitopes

US8986700B2 · kind B2 · utility

Assignee

• The Council of the Queensland Institute of Medical Research · AU

Inventors

• David Charles Jackson · Elmore, AU
• Weiguang Zeng · Sydney, AU

Key dates

• Filing date: Oct 8, 2010
• Grant date: Mar 24, 2015
• Expiry date: Oct 3, 2032

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2770/24234
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and CTL epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular CTL epitopes. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the CTL epitope.