Nanopore sequencing devices and methods

US8986928B2 · kind B2 · utility

Assignee

• PACIFIC BIOSCIENCES OF CALIFORNIA, INC. · US

Inventors

• Stephen Turner · Menlo Park, US
• Benjamin Flusberg · Atlanta, US
• Mathieu Foquet · San Jose, US
• Hans Callebaut · Mountain View, US
• Robert Sebra · San Francisco, US
• Bidhan Chaudhuri · San Jose, US
• Jon Sorenson · Alameda, US
• Keith Bjornson · Fremont, US
• Adrian Fehr · San Francisco, US
• Jonas Korlach · Camas, US
• Robin Emig · Belmont, US

Key dates

• Filing date: Apr 9, 2010
• Grant date: Mar 24, 2015
• Expiry date: Nov 13, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2565/631
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to devices and methods for nanopore sequencing. The invention includes arrays of nanopores having incorporated electronic circuits, for example, in CMOS. In some cases, the arrays of nanopores comprise resistive openings for isolating the electronic signals for improved sequencing. Methods for controlling translocation of through the nanopore are disclosed.