Expansion of stem/progenitor cells by inhibition of enzymatic reactions catalyzed by the Sir2 family of enzymes
US8986992B2 · kind B2 · utility
3Cited by
2References
14Claims
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Key dates
| Filing date | Apr 17, 2012 |
| Grant date | Mar 24, 2015 |
| Priority date | — |
| Expiry date | Nov 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2501/70
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided are ex vivo and in vivo methods of expanding renewable stem cells using agents capable of down-regulating Sir2 protein activity and/or expression, expanded populations of renewable stem cells, and uses thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.