Substituted pyridines and pyrimidines

US8986994B2 · kind B2 · utility

Assignee

• Technische Universität Wien · AT

Inventors

• Marko Mihovilovic · Perchtoldsdorf, AT
• Michael Schnuerch · Maissau, AT
• Moumita Koley · Bengaluru, IN
• Karlheinz Hilber · Wien, AT
• Xaver Koenig · Weitensfeld im Gurktal, AT

Key dates

• Filing date: Dec 28, 2010
• Grant date: Mar 24, 2015
• Expiry date: Dec 28, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2500/40
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided are compounds of formula (I) and/or salts thereof, of the class of substituted pyridines and pyrimidines, useful for inducing cardiomyogenesis, a process for producing cardiomyocyte-like cells from mammalian cells by culturing mammalian cells in the presence of the compound of formula (I), the pharmaceutical use of compounds of formula (I) for producing cardiomyocyte-like cells from omnipotent, pluripotent, or lineage committed mammalian cells, and the use of thus produced cardiomyocyte-like cells for treating disorders associated with impaired function of the heart.