Compositions and methods for treating obesity and diabetes

US8987198B2 · kind B2 · utility

Assignees

• The Administrators of the Tulane Educational Fund · US
• United States Department of Agriculture · US
• Wake Forest University Health Sciences · US
• Nume Health, LLC · US

Inventors

• Matthew E. Burow · New Orleans, US
• Stephen M. Boue · New Orleans, US
• Thomas Wang · Taipei, TW
• Deepak Bhatnagar · New Orleans, US
• Charles E. Wood · Roanoke, US
• Mark L. Helman · New Orleans, US

Key dates

• Filing date: Dec 22, 2010
• Grant date: Mar 24, 2015
• Expiry date: May 19, 2033

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are methods of modulating the expression of genes linked to adipocytokine signaling, carbohydrate metabolism, fatty acid metabolism, arachidonic acid metabolism, PPAR signaling, insulin signaling, lipid metabolism, extracellular matrix (ECM)-receptor interaction, or combinations thereof, methods of treating hyperlipidemia, obesity, excessive cholesterol, cardiovascular disease, liver disease, diabetes, or combinations thereof, and methods of stimulating glucose uptake in an animal in need thereof, comprising administering a composition comprising at least one isolated glyceollin to said animal.