Patent · US Active

N-carboxyalkyl-auristatin and the use thereof

US8987209B2 · kind B2 · utility

5Cited by

8References

16Claims

0Family size

Assignee

SEATTLE GENETICS, INC. · US

Inventors

Hans-Georg Lerchen · Leverkusen, DE
Sherif El Sheikh · Essen, DE
Beatrix Stelte-Ludwig · Wülfrath, DE
Sven Golfier · Berlin, DE
Joachim Schuhmacher · Wuppertal, DE
Jean Mark Gnoth · Mettmann, DE
Ursula Krenz · Leichlingen, DE

Key dates

Filing date	Sep 26, 2011
Grant date	Mar 24, 2015
Priority date	—
Expiry date	Sep 26, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61K38/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present application relates to new derivatives of monomethylauristatin F, substituted on the N terminus by a carboxyalkyl group, processes for preparing these derivatives, their use for the treatment and/or prevention of diseases and to produce medication for the treatment and/or prevention of diseases, particularly hyperproliferative and/or angiogenic disorders such as cancer disorders, for example. Such treatments can occur as monotherapies or in combination with other medication or further therapeutic measures.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.