Inhibitors of integrin alpha2beta1 based on prolyl diaminopropionic acid scaffold

US8987306B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• William F. DeGrado · Media, US
• Meredith W. Miller · Philadelphia, US
• Sandeep Basra · Munich, DE
• Joel Bennett · Greensboro, US
• Sungwook Choi · Paju-si, KR

Key dates

• Filing date: Sep 24, 2009
• Grant date: Mar 24, 2015
• Expiry date: Sep 12, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.