Amyloid-beta binding proteins

US8987419B2 · kind B2 · utility

Assignees

• Abb Vie Deutschland Gmbh & Co. KG · DE
• Abb Vie Inc. · US

Inventors

• Stefan Barghorn · Mannheim, DE
• Heinz Hillen · Herbrechtingen, DE
• Andreas Striebinger · Speyer, DE
• Simone Giaisi · Edingen-Neckarhausen, DE
• Ulrich Ebert · Mannheim, DE
• Lorenzo Benatuil · Northborough, US

Key dates

• Filing date: Apr 13, 2011
• Grant date: Mar 24, 2015
• Expiry date: Apr 13, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to amyloid-beta (Aβ) binding proteins. Antibodies of the invention have high affinity to Aβ(20-42) globulomer or any Aβ form that comprises the globulomer epitope. Method of making and method of using the antibodies of the invention are also provided.