Process for the manufacture of Sevoflurane

US8987524B2 · kind B2 · utility

Assignee

• SOLVAY FLUOR GMBH · DE

Inventor

• Max Braun · Großburgwedel, DE

Key dates

• Filing date: Aug 10, 2010
• Grant date: Mar 24, 2015
• Expiry date: Oct 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C67/31
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the manufacture of Sevoflurane CF3—CH(OCH2F)—CF3 which comprises (a) manufacturing a substituted malonic acid derivative of formula (I): R1OOC—CH(OCH2X)—COOR2 or of formula (II): R3HNOC—CH(OCH2X)—CONHR4, wherein X is OH or a leaving group which can be substituted by nucleophilic substitution and wherein R1, R2 R3, R4, equal to or different from each other, are independently selected from the group consisting of H, an alkyl group having from 1 to 10 carbon atoms which is optionally substituted by at least one halogen atom, an aralkyl group, and an aryl group; and (b) further reacting said malonic acid derivative as intermediate for the manufacture of Sevoflurane CF3—CH(OCH2F)—CF3.