System and method for performing tandem mass spectrometry analysis
US8987662B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | May 14, 2009 |
| Grant date | Mar 24, 2015 |
| Priority date | — |
| Expiry date | Dec 3, 2032 |
Classification
- Technology area (CPC H)Electricity
- CPC primaryH01J49/0036
- WIPO fieldElectrical machinery, apparatus, energy
- WIPO sectorElectrical engineering
Abstract
A system for performing tandem mass spectrometry (MS/MS) analysis of a sample includes a mass spectrometer and a processor. The mass spectrometer is configured to perform a mass spectrometry (MS) scan of an ionized sample to provide a mass of an observed peak corresponding to a precursor ion. The processor is configured to perform operations including determining whether the mass of the observed peak matches a mass of at least one of multiple expected peptides on a dynamic watch list, where the expected peptides correspond to a protein in the sample, and calculating a score of an accuracy of the determination when the mass of the observed peak is determined to match the mass of at least one of the plurality of expected peptides. The precursor ion is excluded from an MS/MS scan when the accuracy score indicates that the determination is accurate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.