Topical tetracycline compositions
US8992896B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 27, 2014 |
| Grant date | Mar 31, 2015 |
| Priority date | — |
| Expiry date | Aug 27, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/33
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.