Antagonist antibodies against GDF-8 and uses therefor
US8992913B2 · kind B2 · utility
25Cited by
34References
24Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 12, 2013 |
| Grant date | Mar 31, 2015 |
| Priority date | — |
| Expiry date | Jun 12, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The disclosure provides improved neutralizing anti-GDF-8 antibodies capable of substantially higher levels of expression in host cells compared to previous anti-GDF-8 antibodies. Also provided are methods of using compositions comprising such antibodies to increase muscle mass or strength, and to treat or prevent muscular disorders, neuromuscular disorders, metabolic disorders, adipose tissue disorders or bone disorders.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.