Altered OspA of Borrelia burgdorferi

US8992936B2 · kind B2 · utility

Assignees

• Research Foundation for the State University of New York York · US
• Brookhaven Science Associates, LLC · US
• University of Rochester · US

Inventors

• Benjamin J. Luft · East Setauket, US
• John J. Dunn · Bellport, US
• Shohei Koide · Nagoya, JP
• Catherine L. Lawson · Piscataway, US

Key dates

• Filing date: Jul 17, 2013
• Grant date: Mar 31, 2015
• Expiry date: Jul 17, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.