Bone matrix compositions and methods
US8992965B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Nov 1, 2006 |
| Grant date | Mar 31, 2015 |
| Priority date | — |
| Expiry date | Nov 16, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/40
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.