Controlled release compositions comprising a combination of isosorbide dinitrate and hydralazine hydrochloride
US8992973B2 · kind B2 · utility
4Cited by
4References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2012 |
| Grant date | Mar 31, 2015 |
| Priority date | — |
| Expiry date | Sep 7, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P9/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a controlled release composition comprising a combination of isosorbide dinitrate and hydralazine, such as hydralazine hydrochloride, that in operation delivers the drug in a pulsed or multi-modal manner for the treatment of angina, ischaemic heart disease, arterial hypertension and related disease conditions. Preferably, the isosorbide dinitrate and hydralazine hydrochloride can be released from the dosage form in an erodable, diffusion and/or osmotic-controlled release profile.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.