Patent · US Active

Antibodies for the detection of integrin complexes in FFPE material

US8993261B2 · kind B2 · utility

0Cited by

4References

21Claims

0Family size

Assignee

Merck Patent GmbH · DE

Inventors

Simon Goodman
Claudia Wilm · Darmstadt, DE
Francesc Mitjans · Igualada, ES

Key dates

Filing date	Mar 15, 2013
Grant date	Mar 31, 2015
Priority date	—
Expiry date	Mar 15, 2033

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/70546
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

The invention relates to antibodies that are capable to bind the extracellular domain of integrin. Another object of the invention concerns the use of said antibodies for detecting integrins in archival formalin fixed paraffin embedded (FFPE) tissue. The invention also relates to methods for preparing monoclonal rabbit antibodies, wherein the immunogen is an insect expression culture-derived recombinant extracellular integrin domain, and another method for screening anti-integrin antibodies that discriminate between closest integrin homologues and that are especially suited for immunohistochemistry in FFPE material.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.