Patent · US Active

2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors

US8993573B2 · kind B2 · utility

0Cited by

38References

10Claims

0Family size

Assignee

AB SCIENCE · FR

Inventors

Marco Ciufolini · Vancouver, CA
Camille G. Wermuth · Strasbourg, FR
Bruno Giethlen · Altorf, FR
Alain Moussy · Paris, FR

Key dates

Filing date	Nov 26, 2013
Grant date	Mar 31, 2015
Priority date	—
Expiry date	Nov 26, 2033

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/14
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Novel compounds selected from 2-(3-aminoaryl)amino-4-aryl-thiazoles of formula (I) that selectively modulate, regulate, and/or inhibit signal transductions mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative metabolic, allergic and degenerative disorders. More particularly, these compounds are potent and selective c-kit inhibitors.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.