N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators

US8993593B2 · kind B2 · utility

Assignee

• Valeant Pharmaceuticals International, Inc. · US

Inventors

• Jean-Michel Vernier · Laguna Niguel, US
• Martha Alicia De La Rosa · Morrisville, US
• Huanming Chen · Irvine, US
• Jim Zhen Wu · Shanghai, CN
• Gary Lee Larson · Cypress, US
• Ian Wayne Cheney · Port Coquitlam, CA

Key dates

• Filing date: Feb 1, 2010
• Grant date: Mar 31, 2015
• Expiry date: Jul 20, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a compound of formula AThe compound provided herein can affect the opening of, or otherwise modulate, voltage-gated potassium channels. The compound provided herein is useful for the treatment and prevention of diseases and disorders which are affected by activation or modulation of potassium ion channels. One such condition is seizure disorders.