Substituted pyrrolidine-2-carboxamides

US8993614B2 · kind B2 · utility

Assignee

• F. Hoffmann-La Roche AG · CH

Inventors

• David Joseph Bartkovitz · Nutley, US
• Xin-Jie Chu · Livingston, US
• Binh Thanh Vu · North Caldwell, US
• Chunlin Zhao · Shanghai, CN
• Daniel Fishlock · Basel, CH

Key dates

• Filing date: Mar 5, 2013
• Grant date: Mar 31, 2015
• Expiry date: Mar 5, 2033

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H15/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There are provided compounds of the formulawherein X, Y, Z, R1, R2, R3 and R4 are as described hereinand enantiomers and pharmaceutically acceptable salts and esters thereof. The compounds are useful as anticancer agents.