Method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt) containing N-acetyllactosamine

US8993740B2 · kind B2 · utility

Assignee

• GLYCOM A/S · DK

Inventors

• István Bajza · Debrecen, HU
• Gyula Dekany · Budapest, HU
• Károly Ágoston · Zsámbék, HU
• Ignacio Figuero-Pérez · Miami, US
• Julien Boutet · Saint-Nazaire, FR
• Markus Hederos · Svedala, SE
• Ferenc Horváth · Pilisszentkereszt, HU
• Piroska Kovács-Pénzes · West Babylon, US
• Lars Kröger · Hamburg, DE
• Christoph Röhrig · Clingen, DE
• Andreas Schroven · Templin, DE
• Ioannis Vrasidas · Thessaloniki, GR
• Péter Trinka · Budapest, HU
• László Kalmár · Alvalade, PT
• Irme Kovács · Debrecen, HU
• Sándor Demkó · Debrecen, HU
• Ágnes Ágoston · Zsámbék, HU
• Christian Risinger · Rottweil, DE

Key dates

• Filing date: Feb 21, 2011
• Grant date: Mar 31, 2015
• Expiry date: Feb 21, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A23V2002/00
• WIPO field: Food chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to a method for preparation of the tetrasaccharide lacto-N-neotetraose (LNnt, formula (I)) especially in large scale, as well as intermediates in the synthesis, a new crystal form (polymorph) of LNnt, and the use thereof in pharmaceutical or nutritional compositions.