Chimeric surface active proteins

US8993743B2 · kind B2 · utility

Assignee

• B.R.A.I.N. Biotechnology Research and Information Network AG · DE

Inventors

• Guido Meurer · Seeheim-Jugenheim, DE
• Esther Gabor · Zwingenberg, DE
• Anke Bachert · Emmelshausen, DE
• Jürgen Eck · Bensheim, DE

Key dates

• Filing date: Feb 18, 2011
• Grant date: Mar 31, 2015
• Expiry date: Feb 18, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/62
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an N-terminal portion of a first surface active protein, wherein the N-terminal portion is devoid of between 0 and 10 of the most N-terminal amino acids of the mature first surface active protein; and, C-terminally thereof, (b) a C-terminal portion of a second surface active protein, wherein the C-terminal portion is devoid of between 0 and 10 of the most C-terminal amino acids of the mature second surface active protein. The present invention further relates to a vector, a non-human host and a method for the production of a chimeric protein having the biochemical activity of a surface active protein. In addition, the present invention relates to a chimeric protein encoded by the nucleic acid molecule of the invention and a composition comprising the chimeric protein. The chimeric protein may only consist of the above mentioned core of (a) and (b), but may also be flanked by additional components of the core, i.e. (a) or (b) or by (an) additional complete core(s) (a) and (b). The present invent…