Use of oripavine as a starting material for buprenorphine
US8993764B2 · kind B2 · utility
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Key dates
| Filing date | Dec 18, 2006 |
| Grant date | Mar 31, 2015 |
| Priority date | — |
| Expiry date | Feb 22, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
There is provided a method for the synthesis of norbuprenorphine, and ultimately buprenorphine, utilizing oripavine as the starting material. Conventional methods of producing buprenorphine utilize thebaine as the starting material, requiring an O-demethylation step, typically a low to moderate yield transformation. The present use of oripavine as a starting material does not require an O-demethylation step, since the oripavine molecule lacks an O-3 methyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.