Oncotherapeutic application of inhibitors of high-affinity glucose transporters
US8999326B2 · kind B2 · utility
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1References
26Claims
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Assignee
Inventor
Key dates
| Filing date | Aug 15, 2008 |
| Grant date | Apr 7, 2015 |
| Priority date | — |
| Expiry date | Jan 11, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The subject invention concerns materials and methods for treating oncological disorders in a person or animal using any agent or compound that inhibits uptake of glucose into a cell. The subject invention also concerns methods for inducing apoptosis and inhibiting the proliferation or survival of a cell. In one embodiment, the methods comprise administering an effective amount of an agent or compound that inhibits the activity of one or more glucose transporter proteins, such as Glut-1. An antibody that binds to and inhibits a glucose transporter protein can be used in the present methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.