Vector comprising multiple homologous nucleotide sequences
US8999637B2 · kind B2 · utility
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5References
9Claims
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Inventor
Key dates
| Filing date | Nov 20, 2009 |
| Grant date | Apr 7, 2015 |
| Priority date | — |
| Expiry date | Jul 21, 2030 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/22
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to vectors comprising two or more homologous nucleotide sequences and methods for generating them. The invention concerns substituting bases in the homologous nucleotide sequences with different bases that do not alter the encoded amino acid sequence. The invention allows for the reduction of intramolecular recombination between homologous nucleotide sequences, in particular in mammalian cells. The invention further relates to nucleotide sequences containing substituted bases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.