Patent · US Active

Compositions and methods for inhibiting the interaction between CFTR and CAL

US8999919B2 · kind B2 · utility

4Cited by

0References

14Claims

0Family size

Assignee

TRUSTEES OF DARTMOUTH COLLEGE · US

Inventors

Dean R. Madden · Hanover, US
Patrick R. Cushing · Hanover, US
Prisca Boisguearin · Berlin, DE
Rudolph Volkmer · Prenzlau, DE
Lars Vouilleme · Berlin, DE

Key dates

Filing date	Nov 9, 2011
Grant date	Apr 7, 2015
Priority date	—
Expiry date	Dec 25, 2032

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K14/4703
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention features compositions and methods for increasing the cell surface expression of degradation-prone CFTR proteins and preventing or treating cystic fibrosis. The invention provides peptides and peptidomimetics that selectively inhibit the interaction between CAL and mutant CFTR proteins, thereby stabilizing the CFTR and facilitating transport of the same to the cell surface.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.