Linear peptide antibiotics

US8999922B2 · kind B2 · utility

Assignee

• RQX Pharmaceuticals, Inc. · US

Inventors

• Robert I. Higuchi · Solana Beach, US
• Tucker Curran Roberts · Berkeley, US
• Peter Andrew Smith · San Francisco, US
• David CAMPBELL · San Diego, US
• Prasuna Paraselli · San Diego, US

Key dates

• Filing date: Feb 15, 2013
• Grant date: Apr 7, 2015
• Expiry date: Feb 15, 2033

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined positions of bacterial Signal Peptidases (SPases) and in other embodiments provide for a broad spectrum of antibiotic bioactivity. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.