Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof

US8999936B2 · kind B2 · utility

Assignee

• BioArctic Neruoscience AB · SE

Inventors

• Pär Gellerfors · Lidingö, SE
• Lars Lannfelt · Stockholm, SE

Key dates

• Filing date: Feb 28, 2013
• Grant date: Apr 7, 2015
• Expiry date: Feb 28, 2033

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/387
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The invention relates to an isolated monoclonal antibody or antigen-binding fragment thereof that (a) binds (i) wild-type Aβ 42/40 protofibril comprising N-terminal truncated Aβ forms and (ii) Aβ 42/40 Arc protofibril comprising N-terminal truncated Aβ forms and (b) has no or little cross-reactivity to Aβ 42/40 monomers. The invention further relates to a method of using such an antibody to treat Alzheimer's disease.