SHIP1 modulators and related methods

US9000050B2 · kind B2 · utility

Assignee

• University of British Columbia · CA

Inventors

• Xiaoxia Wang · Shanghai, CN
• Labros Meimetis · Somerville, US
• Matthew Nodwell · San Francisco, US
• Raymond Andersen · Vancouver, CA

Key dates

• Filing date: Aug 22, 2011
• Grant date: Apr 7, 2015
• Expiry date: Aug 22, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/40
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2 and A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed.